造血干细胞移植与细胞治疗

本书涵盖了造血干细胞移植的历史进展和应用、科学基础、患者相关问题、细胞来源、获得性疾病的造血干细胞移植、造血干细胞移植治疗先天性疾病和移植后相关并发症处理等多方面内容，是造血干细胞移植领域权威的工具书。既可作为血液和骨髓移植领域的临床医生和研究人员、血液学家和肿瘤学家、输血医学专家的案头工具书，又可为移植工作中的相关医务人员提供细致的学术参考资料。

\"张曦，陆军军医大学（第三军医大学）新桥医院内科学（血液病）专业教授。 现任陆军军医大学第二附属医院(新桥医院)血液科主任。 2018年5月，获聘2017年度“长江学者奖励计划”特聘教授，所聘岗位为内科学（血液病）。 2021年11月3日，张曦主持的项目“难治性白血病诊治新策略的建立与临床应用”获2020年度国家科学技术进步奖二等奖。\"

\\\"造血干细胞移植与细胞治疗 第一部分?引言和生物学特征 第一章 造血干细胞移植的过去、现在和未来 ······················································2 第二章 人类白细胞抗原系统在造血干细胞移植中的作用 ····································· 14 第二部分?研究方法 第三章 造血干细胞采集 ··············································································· 24 第四章 干细胞移植和细胞治疗中的贝叶斯统计方法 ··········································· 31 第三部分 ? 移植的一般临床工作 第五章 移植准备工作中的患者和供者评估 ······················································· 46 第六章 造血干细胞移植期间的输血支持 ·························································· 55 第七章 单倍体造血干细胞移植 ······································································ 66 第八章 脐血移植························································································· 81 第九章 患者接受嵌合抗原受体治疗的流程和综合管理 ········································ 92 第四部分?药理学和放射治疗 第十章 造血干细胞移植和嵌合抗原受体T细胞疗法的预处理治疗 ································100 第十一章 造血干细胞移植和嵌合抗原受体治疗药物的药理学研究 ························114 第十二章 放射生物学原理和放射治疗在造血干细胞移植和嵌合抗原受体T细胞 治疗中的作用 ··············································································130 第五部分?移植和嵌合抗原受体T细胞治疗的适应证及疗效 第十三章 成人急性髓系白血病的造血干细胞移植 ·············································140 第十四章 嵌合抗原受体疗法治疗急性髓系白血病 ·············································158 第十五章 急性淋巴细胞白血病的异基因造血干细胞移植 ····································167 第十六章 嵌合抗原受体T细胞治疗急性淋巴细胞白血病 ······································181 第十七章 慢性淋巴细胞白血病的造血干细胞移植及细胞治疗 ······························193 第十八章 骨髓增生异常综合征患者的异基因造血干细胞移植 ······························205 第十九章 骨髓增殖性肿瘤的同种异体细胞移植 ················································217 第二十章 异基因造血干细胞移植治疗再生障碍性贫血 ·······································224 第二十一章 多发性骨髓瘤中的造血干细胞移植 ················································232 第二十二章 多发性骨髓瘤的嵌合抗原受体T细胞（CAR-T细胞）疗法 ····················241 第二十三章 造血干细胞移植在轻链型淀粉样变中的应用 ····································262 第二十四章 造血干细胞移植治疗非霍奇金淋巴瘤 ·············································271 第二十五章 造血干细胞移植治疗霍奇金淋巴瘤 ················································283 第二十六章 淋巴瘤的嵌合抗原受体治疗 ·························································293 第二十七章 罕见血液系统恶性肿瘤的造血干细胞移植治疗 ·································304 第二十八章 造血干细胞移植治疗生殖细胞肿瘤及成人其他实体瘤 ························316 第二十九章 自然杀伤细胞：征服癌症的有前途的细胞治疗平台 ···························322 第六部分?并发症的预防和管理 第三十章 造血干细胞移植受者的感染控制、预防与疫苗接种 ······························330 第三十一章 造血干细胞移植受者的感染管理 ···················································343 第三十二章 造血干细胞移植后植入失败 ·························································355 第三十三章 移植物抗宿主病 ········································································362 第三十四章 造血干细胞移植并发症 ·······························································385 第三十五章 靶向CD19嵌合抗原受体疗法的细胞因子释放综合征 ··························406 第三十六章 嵌合抗原受体疗法的神经系统并发症 ·············································421 第三十七章 嵌合抗原受体T细胞治疗的其他并发症 ············································434 第三十八章 血液系统恶性肿瘤的症状管理和姑息治疗 ·······································444 第三十九章 生存状态 ·················································································454\\\"