Preface
Paolo Pelosi
Claude Guerin
Zhongheng Zhang
Jordi Rello
Ming Zhong
Mechanical Ventilation
Supporting respiratory function in the immunocompromised critically ill patient： new perspectives for an old paradigm
New puzzles for the use of non—invasive ventilation for immunosuppressed patients
Non—invasive ventilation in immunocompromised patients with acute hypoxemic respiratory failure
Conservative versus liberal oxygenation targets for mechanically ventilated patients—a pilot multicenter randomized controlled trial
Permissive hypoxenua／conservative oxygenation strategy： Dr.Jekyll or Mr.Hyde？
From Berlin to Kigali： the sobering journey of acute respiratory distress syndrome
The Kigali modification of the berlin definition： a new epidemiological tool for ARDS？
Acetazolamide use in severe COPD exacerbaoons requiring invasive mechanical ventilation： impact on duration of mecharucal ventilation
Intraoperative mechanical ventilation in patients with non—injured lungs： time to talk about tailored protective ventilation？
One more brick in the wall of protective ventilation in surgical patients
"Open the lung and keep it open"： a homogeneously ventilated lung is a 'healthy lung'
How to improve assessment of balance in baseline characteristics of clinical trial participants—example from PROSEVA trial data？
Quantification oflung recruitment by respiratory mechanics and CT imaging： what are the clinical implications？
Sepsis and Infection
Fever： suppress or let it ride？
Acetaminophen in critically ill patients， a therapy in search for big data analytics
Acetaminophen for febrile patients with suspected infection： potential benefit and further directions
Is there a role for continuous infusion of p—lactam antibiotics in severe sepsis？
Balanced control of both hyper and hypo—inflammatory phases as a new treatment paradigm in sepsis
Septic shock in the era of preasion medicine
Sepsis without SIRS is still sepsis
Why we need a new definition of sepsis
Forget skin scrubbing and other antiseptics： prevent catheter related infections using chlorhexidine plus alcohol
A multimodality approach to prevent catheter—related bloodstream infections： the role of chlorhexidine— alcohol as a skin antiseptic before intravascular catheter insertion
What is new for the prevention of catheter—related bloodstream infections？
Venous—to—arterial carbon dioxide differences and the microcirculation in sepsis
Venous—to—arterial Co2 differences and the quest for bedside point—of—care monitoring to assess the microcirculation during shock
Choice of crystalloids in sepsis：a conundrum waiting to be solved
Preventing the development of acute cor pulmonale in patients with acute respiratory distress syndrome： the first step
Edjtorial on low—dose acetylsalicylic acid treatme't and imp：htortnsshdy —term mortality in stapbylococcus aureus bloodstream infection： a propensity score—matched cohe ，
Cardiac Arrest and CPR
Continuous or interrupted chest compressions for EMS—performed cardiopulmonary resuscitation
To interrupt， or not to interrupt chest compressions for ventilation： that is the question！
What can a simple measure of heart rate during temperature management tell us on the physiology and prognosis ofcomatose cardiac arrest patienrs？
Outcome for the Critically ill
A modified Sequential Organ Failure Assessment score using the Richmond Agitation—Sedation Scale in critically ill patients
Serum creatinine level， a surrogate of muscle mass， predicts mortality in critically ill patients
Utility of the Richmond Agitation—Sedation Scale in evaluation of acute neurologic dysfunction in the intensive care unit
Serum lactate level as a useful predictor of clinical outcome after surgery： an unfulfilled potential？
Lactate： the "Black Peter" in high—risk gastrointestinal surgery patients
Delirium and Sedation
Can the critical—care pain observation tool （CPOT） be used to assess pain in delirious ICU patients？
The impact of sedation protocols on outcomes in critical illness
The best sedation drug—a quest for the holy grail？
Sedative choice and ventilator—associated patient outcomes： don't sleep on delirium
Extracorporeal Support
The delicate balance between pro—（risk of thrombosis） and anti—（risk of hleeding） coagulation during extracorporeal memhrane oxygenation
Hemostatic changes during extracorporeal membrane oxygenation： a commentary
Methodology of Study Design
Challenging orthodoxy in critical care trial design： physiological responsiveness
