生物化学 留学生与双语教学用(原著第4版) 英文原版改编版

《生物化学》第四版保留了清晰的文字、强有力的物理化学背景，并使用“生物化学工具”的特点来强调生物化学的实验性质。这一版已经全面和一致地更新，以目前在一个快速发展的领域的发展。

本教材在充分尊重原著的基础上，保留其基本框架，参考清华大学出版社出版的《来华留学生临床医学专业本科（英语授课）教学大纲》和国家执业医师资格考试大纲进行改编，内容涵盖大分子结构与功能、物质代谢与调节，以及遗传信息传递等。本书编排上力求简明扼要，重点突出，可作为来华留学临床医学学士（MBBS）和我国长学制临床医学专业学生使用的教材，也可作为相关学科的硕士研究生、进修生和教师的参考书。

杨洁，教授，博导。1997年7月中山医科大学生化博士毕业后执教医学基础课程-生化与分子生物学多年，承担了五年制、七年制、留学生和研究生的《生物化学》课程以及研究生的《分子生物学进展》等课程，积累了大量教育教学经验。2007年被评为天津市优秀教师，国家教育部新世纪人才支持计划、天津市特聘教授。参编专著《分子遗传学与基因工程》，人卫教材《医学细胞生物学》、《医学免疫学》。现今为中华医学会医学细胞生物学常务委员、中华微生物与免疫学会青年委员会副主委、临床生物化学与分子生物学会理事、中国细胞生物学会医学细胞生物学分会理事、天津市生化与分子生物学常务理事。作为基础医学院的院长，对基础医学课程体系及规范课程的改革和优化做出了积极的推动作用。作为211重点学科带头人，2006年以来获得863、国家基金面上、重大研究计划培育等科研项目，在Nat Struct Mol Biol.，JBC.，NAR等国际杂志发表SCI收录论文10余篇，培养研究生18名。

PART 1 The Realm of Biochemistry
CHAPTER 1 The Scope of Biochemistry
Biochemistry and the Biological Revolution
The Roots of Biochemistry
Biochemistry as a Chemical Science
Biochemistry as a Biological Science
Biochemistry and the Information Explosion
PART 2 Molecular Architecture of Living Matter
CHAPTER 2 Nucleic Acids
The Nature of Nucleic Acids
Primary Structure of Nucleic Acids
Secondary and Tertiary Structure of Nucleic Acids
The Biological Functions of Nucleic Acids:A Preview of Molecular Biology
Plasticity of Secondary and Tertiary DNA Structure
Stability of Secondary and Tertiary Structure
CHAPTER 3 Introduction to Proteins:The Primary Level of Protein Structure
Amino Acids
Peptides and the Peptide Bond
Proteins:Polypeptides of Defined Sequence
From Gene to Protein
Protein Sequence Homology
CHAPTER 4 The Three-Dimensional Structure of Proteins
Secondary Structure:Regular Ways to Fold the Polypeptide Chain
Fibrous Proteins:Structural Materials of Cells and Tissues
Globular Proteins:Tertiary Structure and Functional Diversity
Factors Determining Secondary and Tertiary Structure
Prediction of Secondary and Tertiary Protein Structure
Quaternary Structure of Proteins
CHAPTER 5 Protein Function and Evolution
Oxygen Transport:The Roles of Hemoglobin and Myoglobin
The Mechanism of Oxygen Binding by Heme Proteins
Oxygen Transport:Hemoglobin
Allosteric Effectors of Hemoglobin
Protein Evolution:Myoglobin and Hemoglobin as Examples
Hemoglobin Variants:Evolution in Progress
PART 3 Dynamics of Life:Catalysis and Metabolism
CHAPTER 6 Enzymes:Biological Catalysts
The Role of Enzymes
Chemical Reaction Rates and the Effects of Catalysts:A Review
How Enzymes Act as Catalysts:Principles and Examples
Enzyme Inhibition
Cofactors,Vitamins,and Essential Metals
The Diversity of Enzymatic Function
Nonprotein Biocatalysts:Catalytic Nucleic Acids
The Regulation of Enzyme Activity:Allosteric Enzymes
Covalent Modifications Used to Regulate Enzyme Activity
CHAPTER 7 Chemical Logic of Metabolism
A First Look at Metabolism
Freeways on the Metabolic Road Map
Biochemical Reaction Types
Some Bioenergetic Considerations
Major Metabolic Control Mechanisms
CHAPTER 8 Carbohydrate Metabolism:Glycolysis,Gluconeogenesis,Glycogen Metabolism,and the Pentose Phosphate Pathway
Glycolysis:An Overview
Reactions of Glycolysis
Metabolic Fates of Pyruvate
Energy and Electron Balance Sheets
Gluconeogenesis
Coordinated Regulation of Glycolysis and Gluconeogenesis
Entry of Other Sugars into the Glycolytic Pathway
Polysaccharide Metabolism
Glycogen Metabolism in Muscle and Liver
Coordinated Regulation of Glycogen Metabolism
Biosynthesis of Other Polysaccharides
A Biosynthetic Pathway That Oxidizes Glucose:The Pentose Phosphate Pathway
CHAPTER 9 Citric Acid Cycle
Overview of Pyruvate Oxidation and the Citric Acid Cycle
Pyruvate Oxidation:A Major Entry Route for Carbon into the Citric Acid Cycle
Coenzymes Involved in Pyruvate Oxidation and the Citric Acid Cycle
Action of the Pyruvate Dehydrogenase Complex
The Citric Acid Cycle
Stoichiometry and Energetics of the Citric Acid Cycle
Regulation of Pyruvate Dehydrogenase and the Citric Acid Cycle
CHAPTER 10 Electron Transport and Oxidative Phosphorylation
Electron Transport
Oxidative Phosphorylation
CHAPTER 11 Lipid MetabolismⅠ:Fatty Acids,Triacylglycerols,and Lipoproteins
Utilization and Transport of Fat and Cholesterol
Fatty Acid Oxidation
Fatty Acid Biosynthesis
CHAPTER 12 Interorgan and Intracellular Coordination of Energy Metabolism in Vertebrates
Interdependence of the Major Organs in Vertebrate Fuel Metabolism
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