药用高分子

  

《药用高分子》基于现代药剂学的发展，依据靠前外很新资料，结合作者多年来的教学科研实践编写而成，系统讲述了高分子在药物制剂中的应用。全书共分为十章，具体内容包括：药用高分子化学基础理论（靠前章）；药用高分子的原理与结构（第二章）；天然来源与合成药用高分子（第三章）；天然来源高分子在药学领域的应用（第四章）；疏水性高分子聚合物的药用价值（第五章）；高分子聚合物在药物传递中的应用（第六章）；医药纳米技术（第七章）；药用高分子的热分析（第八章）；原子力显微镜在药用高分子中的应用（第九章）；药物高分子的流变学研究（第十章）。《药用高分子》可供普通高等医药院校药学、药物制剂、制药工程、高分子材料与工程等相关专业学生及从事药物制剂生产、研究的人员参考使用。

辉，泰山医学院，副教授， 自2004年以来，长期从事高分子材料专业的本、专科的教学，教授的课程主要有材料导论、专业英语、聚合物改性、涂料化学、光化学与光物理、波谱分析、聚合物加工流变学、高分子材料概论等。科研方向为医用高分子材料、高分子界面。

Chapter 1 Fundamentals of Pharmaceutical Polymer Chemistry1
1.1 The Concept of a Polymer1
1.2 Addition Polymerization4
1.3 Chain Branching; Graft and Block Copolymers15
1.4 Polymer Structure and Properties18
1.5 Technology of Polymerization24
1.6 The Principal Monomers and Their Polymers27
1.7 Physical Properties of Monomers37
References41
Chapter 2 Pharmaceutical Polymers: Principles and Structures42
2.1 Introduction42
2.2 Intra and Inter Polymer Molecular Interactions45
2.3 Molecular Mass: Polydispersivity and Effects on Polymer Viscosity47
2.4 Thermal Properties: Effect of Crystalline and Amorphous Phases51
2.5 Mechanical Properties of Polymers54
2.6 Pharmaceutical Polymers: Principles, Structures, and Applications of Pharmaceutical Delivery Systems61
References80
Chapter 3 Polymers as Drugs81
3.1 Introduction81
3.2 Polymers for Molecular Sequestration83
3.3 Polyvalent Interactions and Anti-Infective Polymeric Drugs 95
3.4 Polymeric Drugs for the Treatment of Autoimmune Diseases105
3.5 Polymeric Anti-Obesity Drugs107
3.6 Polymer Therapy for Sickle Cell Disease111
3.7 Conclusions and Outlook on Polymers as Drugs112
References113
Chapter 4 Pharmaceutical Applications of Natural Polymers114
4.1 Introduction114
4.2 Portals of Drug Administration in the Human Body116
4.3 Transdermal Drug Delivery Devices117
4.4 Topical Drug Delivery124
4.5 Oral Drug Delivery System131
4.6 Parenteral Drug Delivery Systems132
4.7 Nasal Drug Delivery Systems134
4.8 Hydrogel-Based Drug Delivery Systems136
References147
Chapter 5 Hydrophobic Polymers of Pharmaceutical Significance149
5.1 Introduction149
5.2 Examples of Hydrophobic Polymers and Their Drug Delivery Applications150
5.3 Conclusions167
References168
Chapter 6 Polymers in Drug Delivery169
6.1 Evolution of Drug Dosage Forms169
6.2 Polymer Excipients172
6.3 Polymers as Manufacture Aids and Sustained Release174
References200
Chapter 7 Pharmaceutical Nanotechnology: Overcoming Drug Delivery Challenges in Contemporary Medicine202
7.1 Challenges in Delivery of Contemporary Therapeutics202
7.2 Nanotechnology Solutions207
7.3 Illustrative Examples of Nanotechnology Products211
7.4 Multifunctional Nanotechnology218
7.5 Regulatory Issues in Nano-pharmaceuticals225
7.6 Conclusions and Future Outlook235
References235
Chapter 8 Thermal Analysis of Pharmaceutical Polymers237
8.1 Introduction237
8.2 Theoretical Background of Thermal Analysis238
8.3 Physical and Chemical Phenomena Commonly Investigated Using Thermal Approaches244
8.4 Applications of Thermal Analysis for the Characterisation of Pharmaceutical Raw Materials248
8.5 Applications of Thermal Analysis for the Characterisation of Pharmaceutical Dosage Forms250
8.6 Conclusion255
References255
Chapter 9 Applications of AFM in Pharmaceutical Polymers256
9.1 Introduction256
9.2 Use of AFM in Pharmaceutical Sciences263
9.3 AFM Combined With Optical or Spectroscopic Techniques271
9.4 Summary271
References273
Chapter 10 Rheology in Pharmaceutically Used Polymers274
10.1 Introduction274
10.2 Theoretical Background and Fundamental Concepts275
10.3 Practical Issues of Rheological Measurements289
10.4 Application of the Technique292
10.5 Summary297
References297