（2）Therapeutic uses
（a）Fenofibrate can be used to treat hyperlipidemia of several etiologies，especially hypertriglyceridemia due to dysbetalipoproteinemia，a defect in apolipopro—tein E that irepairs clearance of chvlomicron remnants and VLDL.
（b）Fenofibrate is ineffective in primary chylomicronemia（caused by a deficiency in lipoprotein lipase）and has little effect on reducing plasma cholesterol levels.
（c）Fenofibrate has antidiuretic action in individuals with mild or moderate diabetes insipidus.
（3）Adverse effects and contraindications
（a）Fenofibrate produces cholelithiasis and cholecgstitis，GI intolerance，nausea，mild diarrhea，and mvalgia.
（b）This drug frequently causes dermatologic reactions and drowsiness，as well as decreased libido in a small percentage of men.
（c）Fenofibrate can displace other albumin—bound drugs，most notably the sulfonylureas and warfarin.
（d）Fenofibrate must be used cautiously in individuals with impaired renal or hepatic function.
b.Gemfibrozil（Lopid）
（1）Gemfibrozil is a fibrate that is more effective than fenofibrate in some circumstances and has some unique biologic activities.
（2）The therapeutic uses of gemfibrozil are identical to those of fenofibrate；it mav be more active in reducing triglvcerides than fenofibrate.
