List of Contributors
Preface
1.Natural Bone Tissue and Its Biomimetic Zhi-Ye Qiu, Yun Cui and Xiu-Mei Wang
1.1 Natural Bone Composition and Hierarchical Structure
1.1.1 Bone Composition
1.1.2 Bone Structure
1.2 Natural Bone Formation Patterns and Bone Repair
1.2.1 Bone Generation Model
1.2.2 Fracture Healing and Bone Remodeling
1.3 Bone Defect Repair Materials
1.3.1 Bone Tissue Engineering
1.3.2 Bone Defect Repair Materials
References
2.Preparation and Characterization of Biomimetic Mineralized Collagen Yun Cui, Helen Cui and Xiu-Mei Wang
2.1 The Basic Principles of Biomineralization
2.1.1 Biological Mineralization Interface Control
2.1.2 Natural Bone Formation and Mineralization
2.2 Bionic Mineralization Research
2.2.1 Hierarchical Structure
2.2.2 Prebuilt
2.2.3 Highly Ordered Self-assembly
2.3 Multilevel Process
2.3.1 Ball
2.3.2 Construction Phase
2.4 Mineralized Collagen Nanofibers Multilevel Self-assembly and its Application in the Regeneration of Bone Engineering
2.4.1 Transmission Electron Microscopy
2.4.2 Scanning Electron Microscopy
2.4.3 Crystal Structure
2.5 High-Strength Mineralized Collagen Artificial Bone
2.5.1 General Observation and Density Measurements
2.5.2 High-Strength Mineralized Collagen of Phase
2.5.3 High-Strength Mineralized Collagen Molecular Structure
2.5.4 The Microstructure of High-Strength Mineralized Collagen
2.5.5 Mechanical Properties
2.5.6 In Vitro Biocompatibility
2.5.7 In Vivo Biocompatibility and Stability Evaluations
2.6 Common Market Mineralized Collagen Material
References
3.Biomimetic Mineralized Collagen Biocompatibility Zi-Rui Wang, Yun Cui and Zhi-Ye Qiu
3.1 Cell Response to the Material
3.1.1 Cell Adhesion
3.1.2 Cell Migration
3.1.3 Cell Proliferation and Differentiation
3.1.4 Cell Aggregation
3.1.5 Cell Function
3.2 Biomineralized Collagen Cell Experiments
3.2.1 The Effect of Mineralized Collagen Material and Bone Marrow Mesenchymal Stem Cells Cultured on the Cel Phenotype
3.2.2 Genetic Toxicity of Mineralized Collagen and its Effect on Cultured Cells In Vitro
3.3 The Experimental Evaluation of the Osteoclasts of Mineralized Collagen
3.3.1 Osteogenic Differentiation Gene Expression Profiling of Human Mesenchymal Stem Cells on Hydroxyapatite and Mineralized Collagen
