内容简介
药物代谢动力学是定量研究药物在生物体内的过
程（吸收、分布、代谢和排泄）并运用数学原理和方
法阐述血药浓度随时间变化的规律的一门学科。编委
会根据目前国际研究水平选择30多个研究点对药代动
力学相关最新技术和研究成果进行详细论述，将研究
分析和数据，以文字、图片、表格等形式清晰展现给
读者，为便于内容统一全球各地区作者，全书采用英
文写作。本书内容涉及危重病患者高剂量替加环素药
动学的盲点、抗结核药物在危重病患者体内的药代动
力学、达托霉素在低流量持续患者体内的药代动力学
、左旋氧氟沙星在危重病患者体内的药代动力学及最
佳方案、利妥昔单抗在儿科耐药患者体内的药代动力
学等。本书为读者展现国际一线学者在相关细分领域
的最新研究数据、科研思路、技术逻辑等，针对性及
功能性均较强，适合相关领域专业读者阅读与参考。
目录
Chapter 1
Pharmacokinetics of Ranitidine in Preterm and Term Neonates with
Gastroesophageal Reflux
by Ismael Lares Asseff Graciela Benitez Gaucin, Hugo Judrez Olguin, et al.
Chapter 2
Effects of CYP3A5 Polymorphism on the Pharmacokinetics of a
Once-Daily Modified-Release Tacrolimus Formulation and Acute
Kidney Injury in Hematopoietic Stem Cell Transplantation
by Takaya Yamashita, Naohito Fujishima, Masatomo Miura, et al.
Chapter 3
Antiplasmodial Activity, in Vivo Pharmacokinetics and Anti-Malarial Efficacy
Evaluation of Hydroxypyridinone Hybrids in a Mouse Model
by Ntokozo S. Dambuza, Peter Smith, Alicia Evans, et al.
Chapter 4
Psychomotor Effect Differences between I-Methamphetamine and
d-Methamphetamine are Independent of Murine Plasma and Brain
Pharmacokinetics Profiles
by Tetsuya Nishimura, Kazue Takahata, Yuri Kosugi, et al.
Chapter 5
A Randomised Trial Comparing the Pharmacokinetics and Safety of the
Biosimilar CT-P6 with Reference Trastuzumab
by Francisco J. Esteva, Justin Stebbing, Rebecca N. Wood-Horrall, et al.
Chapter 6
In Viva Therapeutic Efficacy and Pharmacokinetics of Colistin Sulfate in
an Experimental Model of Enterotoxigenic Escherichia coil Infection in
Weaned Pigs
by Mohamed Rhouma, Francis Beaudry, William Th~riault, et al.
Chapter 7
Integration of Pharmacometabolomics with Pharmacokinetics and
Pharmacodynamics: Towards Personalized Drug Therapy
by Vasudev Kantae, Elke H. J. Krekels, Michiel J. Van Esdank, et al.
Chapter 8
A Multicenter, Randomized, Open-Label, Active-Comparator Trial to
Determine the Efficacy, Safety, and Pharmacokinetics of Intravenous
Ibuprofen for Treatment of Fever in Hospitalized Pediatric Patients
by Samia N. KhaN, Barry J. Hahn, Carrie E. Chumpitazi, et al.
Chapter 9
A Clinical Drug-Drug Interaction Study to Evaluate the Effect of a
Proton-Pump Inhibitor, A Combined P-Glycoprotein/Cytochrome 450
Enzyme (CYP)3A4 inhibitor, and a CYP2C9 Inhibitor on the
Pharmacokinetics of Vismodegib
by Vikram Malhi, Dawn Colburn, Sarah J. Williams, et al.
Chapter 10
Safety, Tolerability and Pharmacokinetics of the Fibroblast Growth
Factor Receptor Inhibitor AZD4547 in Japanese Patients with
Advanced Solid Tumours: A Phase I Study
by Hideo Saka, Chiyoe Kitagawa, Yoshihito Kogure, et al.
Chapter 11
Pharmacokinetics of Carfilzomib In Patients with Advanced Malignancies
and Varying Degrees of Hepatic Impairment: An Open-Label, Single-Arm,
