Section I Structure and Function of Biomolecules
Chapter I Structure and Function of Protein
L-a-AMINO ACIDS: STRUCTURE
CLASSIFICATION
Nonpolar Amino Acids
Acidic Amino Acids
Basic Amino Acids
Neutral Amino Acids
ELECTROLYTE AND ACID-BASE PROPERTIES
THREE-DIMENSIONAL STRUCTURE OF PROTEINS AND DISORDERS OF
PROTEIN MISFOLDING
COVALENT AND COORDINATE COVALENT BONDS IN PROTEIN STRUCTURE
NONCOVALENT INTERACTIONS IN PROTEIN STRUCTURE
Attractive Forces
Repulsive Forces
PRIMARY STRUCTURE
Peptide Bond
SECONDARY STRUCTURE
α-Helix
β-Pleated Sheet
β-Turns
Random Coil
Other Types of Secondary Structures
Motifs and Domain
TERTIARY STRUCTURE
QUATERNARY STRUCTURE
DENATURATION
CONVERSION OF PRECURSOR PROTEINS TO ACTIVE PROTEINS BY PROTEOLYSIS
PROTEIN FOI,DING AND INTRACEI.I.III,AR DEGRADATION OF MISFOLDED AND
DEFECTIVE PROTEINS
AUTOPHAGY
Proteolysis (Protein Degradation) by ATP-Dependent Ubiquitin-Proteasome Complex
Components and the Properties of the Ubiquitin-Proteasome System
PROTEIN MISFOLDING AND FIBRILLOGENIC DISEASES
Transmissible Spongiform Encephalopathies
Alzheimer's Disease
Chapter 2 Structure and Function of Nucleic Acids
STRUCTURE AND FUNCTION OF DNA
Discovery of DNA as the Genetic Material
Components of DNA
Base Pairing of Bases in DNA Double Helixes
Phosphodiester Backbone of DNA
Modifications of DNA Bases
Physical and Chemical Structure of DNA
Conformational Changes of the DNA Double Helix
DNA Supercoils
Denaturation of DNA
Renaturation of DNA
CHROMOSOMES AND CHROMATIN
Repetitive DNA Sequences