有机化学中的生物转化(第6版)

费伯所著的《有机化学中的生物转化（第6版） 》主要包括5个部分：引言和背景知识部分对生物催 化剂进行了深入浅出的精练概括和评述；生物催化剂 的应用从多个方面对近几十年来生物催化剂在有机合 成中的应用进行了系统全面的总结；专用技术部分重 点概括了生物催化剂在有机合成中的应用、生物催化 剂的固定化及酶的修饰和人工模拟；技术现状与展望 部分对生物催化剂的现状和未来的发展做了详细介绍 ；附录部分则从实用的角度为读者提供了非常有价值 的信息资料。

1 Introduction and Background lnformation 1.1 Introduction 1.2 Common Prejudices Against Enzymes 1.3 Advantages and Disadvantages of Biocatalysts 1.3.1 Advantages of Biocatalysts 1.3.2 Disadvantages of Biocatalysts 1.3.3 Isolated Enzymes vs. Whole Cell Systems 1.4 Enzyme Properties and Nomenclature 1.4.1 Structural Biology in a Nutshell 1.4.2 Mechanistic Aspects of Enzyme Catalysis 1.4.3 Classification and Nomenclature 1.4.4 Coenzymes 1.4.5 Enzyme Sources References 2 Biocatalytic Applications 2.1 Hydrolytic Reactions 2.1.1 Mechanistic and Kinetic Aspects 2.1.2 Hydrolysis ofthe Amide Bond 2.1.3 EsterHydrolysis 2.1.4 Hydrolysis and Formation ofPhosphate Esters 2.1.5 Hydrolysis ofEpoxides 2.1.6 Hydrolysis of Nitriles 2.2 Reduction Reactions 2.2.1 Recycling ofCofactors 2.2.2 Reduction of Aldehydes and Ketones Using IsolatedEnzymes 2.2.3 Reduction of Aldehydes and Ketones Using Whole Cells 2.2.4 Reduction of C-C-Bonds 2.3 Oxidation Reactions 2.3.1 Oxidation of Alcohols and Aldehydes 2.3.2 Oxygenation Reactions 2.3.3 Peroxidation Reactions 2.4 Formation of Carbon-Carbon Bonds 2.4.1 Aldol Reactions 2.4.2 Thiamine-Dependent Acyloin and Benzoin Reactions 2.4.3 Michael-Type Additions 2.5 Addition and Elimination Reactions 2.5.1 Cyanohydrin Formation 2.5.2 Addition of Water 2.5.3 Addition of Ammonia 2.6 Transfer Reactions 2.6.1 Glycosyl Transfer Reactions 2.6.2 Amino Transfer Reactions 2.7 Halogenation and Dehalogenation Reactions 2.7.1 Halogenation 2.7.2 Dehalogenation References 3 SpeciaI Techniques 3.1 Enzymes in Organic Solvents 3.1.1 Ester Synthesis 3.1.2 Lactone Synthesis 3.1.3 Amide Synthesis 3.1.4 Peptide Synthesis 3.1.5 Peracid Synthesis 3.1.6 Redox Reactions 3.1.7 Medium Engineering 3.2 Immobilization 3.3 Artificial and Modified Enzymes 3.3.1 Artificial Enzyme Mimics 3.3.2 Modified Enzymes 3.3.3 Catalytic Antibodies References 4 State of the Art and Outlook References 5 Appendix 5.1 Basic Rules for Handling Biocatalysts 5.2 Abbreviations 5.3 Suppliers of Enzymes 5.4 Commonly Used Enzyme Preparations 5.5 MajorCulture Collections 5.6 Pathogenic Bacteria and Fungi Index